Effects of natural extracts in the treatment of oral ulcers: a systematic review of evidence from experimental studies in animals

• Wen, SD. ^[2] ; Sans-Serramitjana, E. ^[3] ; Santander, JF. ^[1] ; Sánchez, MR. ^[1] ; Salazar-Aguilar, P. ^[1] ; Zepeda, AB. ^[1] ; Alvarado, SI. ^[1] ; Miranda, IB. ^[1]
  1. [1] Universidad Autónoma de Chile

     Universidad Autónoma de Chile

     Temuco, Chile

     
  2. [2] Grupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Doctoral Program in Morphological Sciences, Universidad de La Frontera, Temuco, Chile
  3. [3] Grupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile. Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile

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• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 13, Nº. 10 (October), 2021, págs. 1038-1048
• Idioma: inglés
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  • Background: To evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models.

    Material and Methods: We carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object.

    Results: A total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of Jasminum grandiflorum, Ficus deltoidea, curcumin and Bixina orellana provoked a significantly greater reduction in the size of the ulcer. Extracts of Salvatora persica, Musa acuminate, Ganoderma lucidum mycelia and Bixina Orellana, as well as preparations of Kouyanqing Granule and curcumin, were able to reduce levels of pro-inflammatory cytokines and increase the expression and serum levels of growth factors and anti-inflammatory cytokines. Extracts of Piper sarmentosus, Cannabis sativa and Bletilla striata provoked a reduction in the severity of the histological inflammation. No significant differences were observed compared to controls in the treatments with extracts of Cannabis sativa, Aloe barbadensus Miller and Malva sylvestris in reducing the area of the oral ulcers.

    Conclusions: Most of the natural extracts described in this review presented a positive clinical and histological effect on the cicatrisation of oral ulcers induced in animal models.