New approaches to cancer treatment: microwire-based magnetic hyperthermia

• O. Mitxelena-Iribarren ^[1] ; I. Martínez de Apellániz ^[1] ; S. Lizarbe-Sancha ^[3] ; S. Arana ^[3] ; Zhukova ^[4] ; Arkady Zhukov ; M. Mujika ^[5]
  1. [1] Universidad de Navarra

     Universidad de Navarra

     Pamplona, España

     
  2. [2] Ikerbasque, Fundación Vasca para la Ciencia

     Ikerbasque, Fundación Vasca para la Ciencia

     Bilbao, España

     
  3. [3] Ceit, Donostia-San Sebastián, Spain
  4. [4] UPV/EHU, 20018, Donostia-San Sebastián, Spain
  5. [5] Ceit, Manuel Lardizábal 15, 20018 Donostia-San Sebastián, Spain

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• Localización: Libro de Actas del XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica / Ma Gloria Bueno García (dir.), 2018, ISBN 978-84-09-06253-9, págs. 245-248
• Idioma: inglés
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• Resumen

  • Although significantly improved, current treatments against cancer still present remarkable drawbacks related mainly to side effects. The effectiveness of surgery, radiotherapy, chemotherapy and their combinations, besides being limited in some cases, does not always make up for the undesired invasive nature of these treatments. Therefore, the need for new approaches to overcome these difficulties is apparent. Targeted therapies appear at this scene as great potential alternatives for oncology. Among them, nanoparticle based magnetic hyperthermia stands out as a valuable technique. Clinical validation steps have highlighted some major hindrances due to clearance and toxicity, though. In this work, a novel hyperthermia approach is presented, where the targeted cell death was achieved by means of glass-coated magnetic microwires. These microvehicles were embedded into an elastomer-based microfluidic chambers, where the target osteosarcoma cells were cultured. For treatment periods below an hour the proposed method was demonstrated to be highly effective against cancer cells killing 85% of the treated population.