Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: A performance

• Ana Carolina Rozalem Reali ^[1] ; Felipe Faria Pierotti ^[1] ; Carolina Sanchez Aranda Lago ^[1] ; Renata Rodrigues Cocco ^[9] ; Emanuel S Cavalcanti Sarinho ^[2] ; Flávio Sano ^[10] ; Arnaldo Porto Neto ^[11] ; Nelson A Rosário ^[3] ; Herberto J Chong Neto ^[3] ; Ekaterini Simões Goudouris ^[4] ; Lilian Sanches Moraes ^[5] ; Neusa Falbo Wandalsen ^[12] ; Antônio Carlos Pastorino ^[6] ; Jackeline Motta Franco ^[7] ; Maria Letícia Chavarria ^[8] ; Magnus P Borres ^[13] ; Dirceu Solé ^[1]
  1. [1] Universidade Federal de São Paulo

     Universidade Federal de São Paulo

     Brasil

     
  2. [2] Universidade Federal de Pernambuco

     Universidade Federal de Pernambuco

     Brasil

     
  3. [3] Universidade Federal do Paraná

     Universidade Federal do Paraná

     Brasil

     
  4. [4] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  5. [5] Universidade Federal de Mato Grosso

     Universidade Federal de Mato Grosso

     Brasil

     
  6. [6] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  7. [7] Universidade Federal de Sergipe

     Universidade Federal de Sergipe

     Brasil

     
  8. [8] Universidade Federal de Goiás

     Universidade Federal de Goiás

     Brasil

     
  9. [9] Pediatrics Department, Albert Einstein Israeli Faculty of Health Sciences, São Paulo, São Paulo, Brazil.
  10. [10] Pediatrics Department, Nipo-Brazilian Hospital, São Paulo, São Paulo, Brazil.
  11. [11] Pediatrics Department, Federal University Fronteira Sul, Passo Fundo, Rio Grande do Sul, Brazil.
  12. [12] Pediatrics Department, Faculty of Medicine, ABC’s Foundation, Santo André, São Paulo, Brazil.
  13. [13] Women’s and Children’s Health, Thermo Fisher Scientific and Uppsala University, Uppsala, Sweden.

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 49, Nº. 5, 2021, págs. 42-48
• Idioma: inglés
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• Resumen

  • The Phadiatop Infant® (PhInf) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months–18 years) were grouped according to their primary disease and age group. PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cow’s milk, peanuts, and shrimp. Values ≥ 0.35 kUA/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country.