Resumen de Application of Annona glabra L. (Annonaceae) in the area of health, chemical composition and biological activity

Luiz Eduardo D’Elia Oliveira, Carlos Manuel Dutok Sánchez, Romário Balieiro Monteiro, Fernando Antônio de Medeiros

• This review article aimed to present the knowledge accumulated so far about the species Annona glabra L. (Annonaceae), its applicability in the health area, chemical composition and biological activity. The selection of articles took place through different bibliographic search platforms, such as Annual Reviews, Europe PMC, Google Scholar, Indian Journals, PubMed, ResearchGate, SAGE journals, Scielo, ScienceDirect, Scientific Reports, Semantic Scholar, Wiley Online Library and J- STAGE The scientific literature presents studies on the species A. glabra present promising data on anticarcinogenic activities, inhibition of carcinogenic cells, chronic lymphocytic leukemia and mitochondrial complex I, antioxidants, antirheumatic, emollient, significant inhibition of HIV replication in H9 lymphocytes and inhibition of reverse transcriptase, antimicrobial, antifungal, insecticidal, vermicide and antiparasitic. Phytochemical studies derived from extractions of different parts of the plant revealed the presence of flavonoids, terpenoids, glycosides, steroids, saponins, tannins, anthraquinones and acidic compounds. The species has properties related to traditional medicine, being used in the Chinese, Japanese and Mexican health systems. The understanding of the species and its compounds with anticarcinogenic activity is still poorly understood and unfortunately no study has reached the clinical testing stage. This study sought to be a source of stimulus for further research addressing the biological activity, in vitro and in vivo studies, of the different floral parts of A. glabra.