Development of scaffolds based on natural materials for tendon tissue regeneration

• Ruiz Alonso ^{[1] [2] [3]} ; Lafuente Merchan Ma ^{[1] [2] [3]} ; Gallego I ^{[1] [2] [3]} ; Saenz Del Burgo L ^{[1] [2] [3]} ; Pedraz JL ^{[1] [2] [3]}
  1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Leioa, España

     
  2. [2] Centro de Investigación Biomédica en Red sobre Bioingeniería, Biomateriales y Nanomedicina

     Centro de Investigación Biomédica en Red sobre Bioingeniería, Biomateriales y Nanomedicina

     Madrid, España

     
  3. [3] Bioaraba Health Research Institute, NanoBioCel Research Group, E-01009 Vitoria-Gasteiz, Spain

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• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 6-8
• Idioma: inglés
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• Resumen

  • Tendon injuries represent a clinical burden on health systems globally. 3D bioprinting could help for the development of scaffolds whose characteristics resemble those of the native tendon. In this study, an ink based on natural materials was developed for tendon tissue regeneration. That ink was characterized and used to print scaffolds by 3D printing. Swelling and degradation rate assays were performed to predict the possible behaviour of the scaffolds in vivo. Finally, tenocytes were incorporated into the inks and 3D bioprinted. The viability and metabolic activity of tenocytes in the scaffold were analyzed.