Resumen de Human serum albumin as a potential nanocarrier for the oral delivery of therapeutic proteins
Cristina Pangua Irigaray, Socorro Espuelas Millán, María Cristina Martínez Oharriz, Juan Manuel Irache Garreta
The oral delivery of therapeutic proteins faces different barriers (pH, enzymes, peristalsis, mucus, etc.) that highly hampers their stability and absorption . In addition, protein drugs have poor oral bioavailability due to their large size and physicochemical characteristics. In order to solve these drawbacks, one alternative may be the combination of nanocarriers with permeation enhancers in order to promote the bioavailability of these drugs. Within this aim, particularly interesting are those permeation enhancers with ionizable groups that may interact with hydrophobic molecules (i.e., proteins) by hydrophobic ion pairing (HIP) resulting in hydrophobic complexes . Furthermore, the encapsulation of these complexes into nanoparticles may protect the loaded protein from its premature degradation and facilitate its release in the epithelium surface. In this context, the aim of this work was to design nanocarriers capable of encapsulating lipophilic complexes of a model protein with hydrophobic counter ions and reaching the surface of the intestinal epithelium
