Biocompatibility of the synthetic biomimetic membrane PermeaPad® with the mucosa of the oral

• El Moussaoui El Masnaoui S ^[1] ; Mireia Mallandrich Miret ^[1] ; Garrós Aristizabal N ^[1] ; Ana C. Calpena Campmany ^[1] ; AC, Rodríguez Laguna MJ ^[1] ; Francisco Fernández Campos ^[2]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Reig-Jofre Laboratories, Av. de les Flors s/n, 08970 Sant Joan Despí, Spain.
• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 148-150
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Animal studies are expensive and complex procedures that require a lot of bureaucracy and material and human resources. To all this, we must add the most important, the ethical and moral aspect of testing drugs and other products on animals. The development of synthetic biomimetic membranes aims to provide a simple solution to all these problems. PermeaPad® biomimetic membranes have been developed to simulate passive mass transfer across different barriers in the body (GIT, buccal, nasal) . To analyze the biocompatibility of these membranes, the permeation results of sodium alginate and hyaluronic acid hydrogel containing 2 % ketorolac tromethamine (KT) through the oral mucosa and the PermeaPad® membranes were correlated.