Resumen de Study of the intestinal permeability of levofloxacin in coperfusion in rats
Elvira Escribano Ferrer, Anallely López Yerena, Álvaro Serrano Nieto, Xavier Garcia Sala
Levofloxacin (Levo) is a drug with an oral bioavailability near 100 % . According to the Biopharmaceutics Classification System it belongs to the class of high permeability. For this reason, the possibility of using Levo as a model drug of high permeability in comparative studies with new substances could be considered. However, in previous studies performed by our group using the in situ single-pass intestinal perfusion technique (SPIP) in rats, very little difference was observed between the concentration of Levo at the entrance and exit of the intestinal segment and thus increasing the variability of the results. For this reason, in order to study the case of intestinal permeability of Levo in more depth, a study of coperfusion of Levo with the high permeability standard metoprolol (Meto) and the low permeability standard acyclovir (Acyclo) was performed.
