COmparisoN of TastES of Available NutriTional integrated or non-integrated formulas for infants older than 1 year of age with cow’s milk allergy: A multicenter, prospective, single blind, cross-sectional observational clinical study (CONTEST Study)

• Derya Ufuk Altıntas ^[1] ; Ipek Turktas ^[2] ; Mustafa Arga ^[7] ; Haluk Cezmi Cokugras ^[8] ; Ersoy Civelek ^[9] ; Ozlem Keskin ^[3] ; Betul Buyuktiryaki ^[4] ; Deniz Ertem ^[5] ; Metin Aydogan ^[10] ; Cıgdem Omur Ecevit ^[11] ; Yesim Ozturk ^[12] ; Zeynep Tamay ^[6] ; Esra Yucel ^[6] ; Gonul Caltepe ^[13] ; Omer Faruk Beser ^[13] ; Nermin Guler ^[6]
  1. [1] Cukurova University

     Cukurova University

     Turquía

     
  2. [2] Gazi University

     Gazi University

     Turquía

     
  3. [3] University of Gaziantep

     University of Gaziantep

     Turquía

     
  4. [4] Koç University

     Koç University

     Turquía

     
  5. [5] Marmara University

     Marmara University

     Turquía

     
  6. [6] Istanbul University

     Istanbul University

     Turquía

     
  7. [7] Pediatric Allergy and Immunology Division, Department of Pediatrics, School of Medicine, Medeniyet University, Istanbul, Turkey
  8. [8] Pediatric Allergy and Immunology Division, Department of Pediatrics, Cerrahpasa School of Medicine, Istanbul, Turkey
  9. [9] Pediatric Allergy and Immunology Division, Ankara Children’s Haematology Oncology Training and Research Hospital, Ankara, Turkey
  10. [10] Pediatric Allergy and Immunology Division, Department of Pediatrics, School of Medicine, Kocaeli University, Kocaeli, Turkey
  11. [11] Pediatric Gastroenterology Division, Health Science University, Dr. Behcet Uz Child Diseases and Pediatric Surgery Training and Research Hospital, Izmir, Turkey
  12. [12] Pediatric Gastroenterology Division, Department of Pediatrics, School of Medicine, 9 Eylul University, Izmir, Turkey
  13. [13] Pediatric Gastroenterology Division, Department of Pediatrics, School of Medicine, 19 Mayıs University, Samsun, Turkey

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 50, Nº. 4, 2022, págs. 97-104
• Idioma: inglés
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  • Palatability of the infant formulas lacking cow milk protein formulas is reported by parents to be an important drawback. The purpose of this study is to examine decisions made by mothers of infants having cow milk protein allergy, and physicians concerning the palatability of unflavored extensively hydrolyzed formulas and amino acid-based formulas. We conducted a multi-center, randomized, single-blinded, observational taste study involving 149 pediatri-cians from gastroenterology and allergy subspecialties at 14 tertiary healthcare units from different regions of Turkey and involving 94 mothers of infants with cow milk protein allergy. Blinding was performed for seven formulas available in the market, which were the most commonly prescribed for feeding: four AAFs (Neocate-Numil®, Aptamil Pregomin AS-Numil®, Alfamino-Nestle®, Comidagen-Mamma®), one AAF specifically designed to address the growing nutritional and lifestyle needs of children >1 year (Neocate Junior-Numil®), 2 eHFs (Bebelac Pepti Junior-Numil®, Similac Alimentum-Abott®). Considering all three formula characteris-tics, Neocate junior-Numil® ranked as the number 1 product among seven products by moth-ers (63.8%) and physicians (69.8%). The ratings of mothers were significantly higher than the physicians (8.1 points and 6.1 points, respectively; p < 0.001). No difference was found in terms of taste, smell, and appearance for Neocate junior-Numil® between the mothers’ and physicians’ ratings. Since caregivers have responsibility for careful selection of replacement products for infants with cow milk protein allergy, it is noteworthy that increased awareness and confidence in the palatability characteristics of these products should motivate mothers and physicians to comply with replacement treatment in the long term