Peripheral ossifying fibroma: a 20-year retrospective study with focus on clinical and morphological features

• Israel Leal Cavalcante ^[3] ; Caio César da Silva Barros ^[1] ; Vitória Maria Sousa Cruz ^[4] ; John Lennon Silva Cunha ^[4] ; Lara Cunha Carneiro Leão ^[5] ; Renata Roque Ribeiro ^[5] ; Eveline Turatti ^[5] ; Bruno Augusto Benevenuto de Andrade ^[2] ; Roberta Barroso Cavalcante ^[5]
  1. [1] Universidade Federal do Rio Grande do Norte

     Universidade Federal do Rio Grande do Norte

     Brasil

     
  2. [2] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  3. [3] Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil; Department of Oral Diagnosis and Pathology, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
  4. [4] Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil
  5. [5] Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 27, Nº. 5 (September), 2022
• Idioma: inglés
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• Resumen

  • Peripheral Ossifying Fibroma (POF) is a reactive hyperplastic lesion that exclusively occurs in the gingiva and is characterized by the deposition of dystrophic calcification, cementum-like tissue, and immature and mature bone within the connective tissue. The objective of the present study was to perform a retrospective analysis of clinicopathologic features of POF.

    Clinical and histopathological data were obtained from biopsy records and histopathological reports from a Brazilian reference service in Oral Pathology (1999 - 2020). Morphological analysis was performed to evaluate features related to the mesenchymal component, inflammatory infiltrate, ulceration, and mineralized tissue.

    A total of 270 POFs were diagnosed during the study period. A higher frequency was observed in females (71.9%) between the third (22.9%) and fourth (23.3%) decades of life. The anterior upper gingiva (29.1%) was the most affected region. Mature (86.7%) and immature (52.6%) bone tissue were the most frequent. There was a significant association between immature bone deposition and lesions with size ≤ 1.7 cm (p = 0.041); immature bone and cement-like tissue deposition with an evolution time ≤ 16 months (p < 0.001); deposition of immature bone and mesenchymal hypercellularization (p < 0.001); deposition of dystrophic calcification and the presence of ulceration (p < 0.001).

    The clinical characteristics corroborate the findings in the literature. The heterogeneous distribution and quantity of mineralized tissues found in the analyzed cases support the theory that the different mineralized tissues constitute a spectrum of clinical maturation of POF.