Embryo metabolism and interaction with culture media
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Roger Sturmey [1]
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[1] University of Hull
University of Hull
Reino Unido
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- Localización: ASEBIR, ISSN-e 1136-4424, Vol. 24, Nº. 2, 2019, 29 págs.
- Idioma: inglés
- Enlaces
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Resumen
For more than 50 years there has been a great interest in the biochemical processes that the maturing oocyte and preimplantation embryo use to generate metabolic energy to support development. Through landmark studies in the 1970s and 1980s, we have a mature understanding the profiles of substrate depletion and accumulation by early embryos as they complete development in vitro, with the discovery of some patterns of metabolism that appear conserved across mammalian embryos. In summary, early embryos have a preference for pyruvate consumption during the cleavage stages, with glucose depletion increasing markedly as the blastocyst is formed. Importantly, it appears as though the majority of cellular energy in the form of ATP is produced through mitochondrial oxidative metabolism, which rises to satisfy energy demand. However, embryo metabolism can be influenced by a great many factors, including maternal physiology, paternal factors and the composition of the environment in which they are cultured.
