Resumen de Small Intestne Biopsy and its Interpretaton:Preliminary Results in Costa Rica
Fernando Brenes Pino, Adelina Herrera Abarca
Celiac disease is an autoimmune disease with diverse histopathological changes of the smallintestne which are fundamental for the diagnosis of the disease. The main changes areintraepithelial lymphocytc infltraton of the intestnal mucosa, with or without villous atrophy.The number of biopsies has to be adequate, at least six, because the histopathologicalabnormalites ofen have a patchy distributon. The disease may exhibit only minimal alteratonsalong with the intraepithelial lymphocytc infltrate, which can be shared with other non-celiacenttes. We recommend the use of the Corazza-Villanacci classifcaton because it hasdemonstrated a beter correlaton among pathologists. We present the results of 258 patents (108 male and 150 female) with celiac disease in CostaRica with lymphocytc duodenits and villous atrophy. Mean age was 48.3 years, ranging between16 and 90 years. Furthermore, in 35 patents, HLA-DQ2 and HLA-DQ8 genotyping was performed;11 cases were positve for HLA-DQ2, 7 for HLA-DQ8, and 3 for both HLA-DQ2 and HLA-DQ8. 15cases were negatve, but had only lymphocytc duodenits, which should be studied further andare currently being followed-up.
