Análisis gwas para resistencia a nematodos gastrointestinales mediante la imputación de genotipos del chip de alta densidad en el ganado ovino

• P.K. Chitneedi ^[1] ; M. Atlija ^[1] ; J.J. Arranz ^[1] ; B. Gutiérrez Gil ^[1]
  1. [1] Universidad de León

     Universidad de León

     León, España

     
• Localización: XVI Jornadas sobre Producción Animal: 19 y 20 de mayo de 2015, Zaragoza / Javier Álvarez Rodríguez (aut.), Begoña Panea Doblado (aut.), Jorge Hugo Calvo Lacosta (aut.), Mireia Blanco Alibés (aut.), José Alfonso Abecia Martínez (aut.), Daniel Villalba Mata (aut.), María Ángeles Latorre Górriz (aut.), Vol. 2, 2015, ISBN 978-84-606-7969-1, págs. 471-473
• Idioma: español
• Títulos paralelos:
  • Gwas analysis for gastrointestinal nematodes resistance traits using imputed high density chip genotypes in sheep
• Enlaces
  • Texto Completo Libro
• Resumen

  • The aim of this study was to identify genomic regions influencing the serum levels of Immunoglobulin A (IgA), an indicator trait of resistance to gastrointestinal nematode (GIN) infections in Spanish Churra dairy sheep. With this aim, we performed a Genome-wide Association Study (GWAS) based on imputed genotypes for the Ovine High Density (HD)-chip for a population of 1,686 animals belonging to 16 different half-sib families. The whole population, including the 16 sires and their daughters had available genotypes for the Ovine 50K-chip. The imputation process was based on the 240 animals of the resource population that had been genotyped for the HD-chip. We estimated the accuracy of imputation, using only the genotypes available for the reference population based on a masking strategy designed to avoid any bias in the accuracy estimation. The GWAS identified a significant SNP at the 5% chromosome-wise level, located on OAR15. As complementary approaches, future analyses will exploit the linkage analysis and combined linkage disequilibrium with linkage analysis to exploit the half-sib structure of the studied resource population.