Urolithin A induces protective autophagy to alleviate inflammation, oxidative stress, and endoplasmic reticulum stress in pediatric pneumonia

• Xingli Cao ^[1] ; Hong Wan ^[2] ; Hao Wan ^[3]
  1. [1] Department of Pediatrics, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an City, Jiangsu Province, China.
  2. [2] Department of Digestive System, Jiangxi Provincial Children’s Hospital, Nanchang, Jiangxi Province, China
  3. [3] Department of Neonatal Surgery, Jiangxi Provincial Children’s Hospital, Nanchang, Jiangxi Province, China

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 50, Nº. 6, 2022, págs. 147-153
• Idioma: inglés
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• Resumen

  • Objective: To investigate the therapeutic effect of urolithin A (UA) on pediatric pneumonia and the underlying mechanisms.

    Methods: The pediatric infantile pneumonia model was constructed by intratracheal induction of lipopolysaccharide (LPS) in 1-week-old C57BL/6 mice (male, 4–5 g). UA was also injected intraperitoneally. Lung tissues in each group were examined by histological analysis. Autophagy, inflammation, and oxidative stress were assessed by enzyme-linked--immunosorbent serologic assay and immunoblot analysis. Moreover, pyrophosis and endoplasmic reticulum stress were also evaluated by immunoblot analysis.

    Results: UA alleviated lung inflammation in mice, and inhibited cell pyrophosis. In addition, UA A relieved both oxidative and endoplasmic reticulum stress. Furthermore, we found that UA alleviated pneumonia damage by inducing protective autophagy.

    Conclusion: UA induced protective autophagy to alleviate inflammation, oxidative stress, and endoplasmic reticulum stress in pediatric pneumonia.