The function of LncRNA-ATB in cancer

• Amir Anbiyaiee ^[4] ; Mohammad Ramazii ^[1] ; Siamak Soltani Bajestani ^[2] ; Seyed Mohammadmahdi Meybodi ^[2] ; Mona Keivan ^[3] ; Seyed Esmaeil Khoshnam ^[5] ; Maryam Farzaneh ^[6]
  1. [1] Kerman University of Medical Sciences

     Kerman University of Medical Sciences

     Irán

     
  2. [2] Islamic Azad University

     Islamic Azad University

     Irán

     
  3. [3] Kermanshah University of Medical Sciences

     Kermanshah University of Medical Sciences

     Irán

     
  4. [4] Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. [5] Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. [6] Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 1 (January), 2023, págs. 1-9
• Idioma: inglés
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• Resumen

  • Cancer as a progressive and complex disease is caused by early chromosomal changes and stimulated cellular transformation. Previous studies reported that long non-coding RNAs (lncRNAs) play pivotal roles in the initiation, maintenance, and progression of cancer cells. LncRNA activated by TGF-β (ATB) has been shown to be dysregulated in different types of cancer. Aberrant expression of lncRNA-ATB plays an important role in the progression of diverse malignancies. High expression of LncRNA-ATB is associated with cancer cell growth, proliferation, metastasis, and EMT. LncRNA-ATB by targeting various signaling pathways and microRNAs (miRNAs) can trigger cancer pathogenesis. Therefore, lncRNA-ATB can be a novel target for cancer prediction and diagnosis. In this review, we will focus on the function of lncRNA-ATB in various types of human cancers.