The role of LncRNA MCM3AP-AS1 in human cancer

• Shirin Azizidoost ^[3] ; Farhoodeh Ghaedrahmati ^[1] ; Mohadeseh Sheykhi-Sabzehpoush ^[4] ; Shahab Uddin ^[5] ; Mehri Ghafourian ^[4] ; Abdolah Mousavi Salehi ^[4] ; Mona Keivan ^[2] ; Maryam Cheraghzadeh ^[6] ; Zahra Nazeri ^[6] ; Maryam Farzaneh ^[7] ; Seyed Esmaeil Khoshnam ^[8]
  1. [1] Isfahan University of Medical Sciences

     Isfahan University of Medical Sciences

     Irán

     
  2. [2] Kermanshah University of Medical Sciences

     Kermanshah University of Medical Sciences

     Irán

     
  3. [3] Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. [4] Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. [5] Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
  6. [6] Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. [7] Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. [8] Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 1 (January), 2023, págs. 33-47
• Idioma: inglés
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• Resumen

  • Long noncoding RNAs (lncRNA) play pivotal roles in every level of gene and genome regulation. MCM3AP-AS1 is a lncRNA that has an oncogenic role in several kinds of cancers. Aberrant expression of MCM3AP-AS1 has been reported to be involved in the progression of diverse malignancies, including colorectal, cervical, prostate, lymphoma, lung, ovary, liver, bone, and breast cancers. It is generally believed that MCM3AP-AS1 expression is associated with cancer cell growth, proliferation, angiogenesis, and metastasis. MCM3AP-AS1 by targeting various signaling pathways and microRNAs (miRNAs) presents an important role in cancer pathogenesis. MCM3AP-AS1 as a competitive endogenous RNA has the ability to sponge miRNA, inhibit their expressions, and bind to different target mRNAs related to cancer development. Therefore, MCM3AP-AS1 by targeting several signaling pathways, including the FOX family, Wnt, EGF, and VEGF can be a potent target for cancer prediction and diagnosis. In this review, we will summarize the role of MCM3AP-AS1 in various human cancers.