The crosstalk between intestinal bacterial miobiota and immune cells in colorectal cancer progressioncr
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Xiaozi Wen [1] ; Xufang Ye [1] ; Xuejun Yang [1] ; Rujin Jiang [1] ; Chunyan Qian [1] ; Xianjun Wang [2]
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[1] Zhejiang University
Zhejiang University
China
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[2] Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 3, 2023, págs. 620-632
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Different types of cells that are involved in tumor immunity play a significant part in antitumor therapy. The intestinal microbiota consist of the trillions of diverse microorganisms that inhabit the gastrointestinal tract. Recently, much emphasis has been paid to the link between these symbionts and colorectal cancer (CRC). This association might be anything from oncogenesis and cancer development to resistance or susceptibility to chemotherapeutic medicines. Cancer patients have a significantly different microbial composition in their guts compared to healthy persons. The microbiome may play a role in the development and development of cancer through the modulation of tumor immunosurveillance, as shown by these studies; however, the specific processes underlying this role are still poorly understood. This review focuses on the relationship between the intestinal bacterial microbiota and immune cells to determine how the commensal microbiome influences the initiation and development of CRC.
