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SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

  • Maria Gonzalez-Cao [16] ; Teresa Puertolas [1] ; Clara Martinez-Vila [17] ; Cristina Carrera [2] ; Cayetana Maldonado Seral [3] ; Pedro Rodríguez-Jiménez [18] ; Silvia Sequero [4] ; Pablo Cerezuela-Fuentes [19] ; Rosa Feltes Ochoa [5] ; Eva Muñoz [20] ; Mónica Antoñanzas Basa [6] ; Juan Martín-Liberal [21] ; Ainara Soria [7] ; Juan Francisco Rodriguez Moreno [22] ; Ivan Marquez-Rodas [8] ; Pilar Lopez Criado [23] ; José Luis Manzano [24] ; Rafael Lopez-Castro [25] ; Pablo Ayala de Miguel [9] ; Laura Villalobos [26] ; Salvador Martin Algarra [10] ; Ines Gonzalez-Barrallo [27] ; Aram Boada [28] ; Almudena García Castaño [29] ; Susana Puig [2] ; Guillermo Crespo [11] ; Pablo Luna Fra [30] ; Cristina Aguayo Zamora [31] ; Marta Feito Rodríguez [5] ; Lara Valles [12] ; Ana Drozdowskyj [32] ; Jesús Gardeazabal [13] ; Luis Antonio Fernandez-Morales [33] ; Alberto Rodrigo [14] ; Raquel Cruz [34] ; Oriol Yelamos [35] ; Belen Rubio [36] ; Karmele Mujica [37] ; Mariano Provencio [15] ; Alfonso Berrocal [38]
    1. [1] Hospital Miguel Servet

      Hospital Miguel Servet

      Zaragoza, España

    2. [2] Universitat de Barcelona

      Universitat de Barcelona

      Barcelona, España

    3. [3] Hospital Universitario Central de Asturias

      Hospital Universitario Central de Asturias

      Oviedo, España

    4. [4] Hospital Universitario San Cecilio

      Hospital Universitario San Cecilio

      Granada, España

    5. [5] Hospital Universitario La Paz

      Hospital Universitario La Paz

      Madrid, España

    6. [6] Hospital Clínico San Carlos de Madrid

      Hospital Clínico San Carlos de Madrid

      Madrid, España

    7. [7] Hospital Ramón y Cajal

      Hospital Ramón y Cajal

      Madrid, España

    8. [8] Hospital General Universitario Gregorio Marañón

      Hospital General Universitario Gregorio Marañón

      Madrid, España

    9. [9] Hospital San Pedro de Alcántara

      Hospital San Pedro de Alcántara

      Cáceres, España

    10. [10] Clínica Universitaria de Navarra

      Clínica Universitaria de Navarra

      Pamplona, España

    11. [11] Complejo Asistencial Universitario de Burgos

      Complejo Asistencial Universitario de Burgos

      Burgos, España

    12. [12] Hospital General de Villalba

      Hospital General de Villalba

      Collado Villalba, España

    13. [13] Hospital de Cruces

      Hospital de Cruces

      Barakaldo, España

    14. [14] Hospital Arnau de Vilanova

      Hospital Arnau de Vilanova

      Valencia, España

    15. [15] Hospital Universitario Puerta de Hierro

      Hospital Universitario Puerta de Hierro

      Madrid, España

    16. [16] Translational Cancer Research Unit, Instituto Oncologico Dr Rosell, Dexeus University Hospital, Barcelona, Spain
    17. [17] Fundación Althaia, Xarxa Assistencial Universitària de Manresa, Barcelona
    18. [18] Dermatology Department, Hospital Universitario la Princesa, Madrid
    19. [19] Medical Oncology Department, Hospital Clinico Universitario Virgen Arrixaca, Murcia
    20. [20] Medical Oncology Department. Hospital, Universitari Vall d’Hebron, Barcelona
    21. [21] Medical Oncology Department, Catalan Institute of Oncology (ICO) Hospitalet, Barcelona
    22. [22] Medical Oncology Department, Centro Integral Oncologico HM Clara Campal, Madrid
    23. [23] Medical Oncology Department, Hospital MD Anderson, Madrid
    24. [24] Medical Oncology Department, Catalonian Institute of Oncology (ICO-Badalona)
    25. [25] Medical Oncology Department, HCU Valladolid
    26. [26] Hospital Principe de Asturias, Alcala de Henares
    27. [27] Hospital Clinico de Valencia
    28. [28] Dermatology Department, Hospital Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Barcelona
    29. [29] Medical Oncology Department, Hospital Marqués de Valdecilla, Santander
    30. [30] Hospital Son Espases, Mallorca,
    31. [31] Hospital Universitario Infanta Sofía, Madrid
    32. [32] Translational Cancer Research Unit, Instituto Oncologico Dr Rosell, Dexeus University Hospital, Barcelona
    33. [33] Hospital Parc Tauli, Sabadell
    34. [34] Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife
    35. [35] Dermatology Department, Hospital Sant Pau, Barcelona
    36. [36] Oncology Department, Hospital Quiron, Madrid
    37. [37] Hospital Donostia, Donostia, Spain
    38. [38] Hospital Universitario General de Valencia
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  • Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 3, 2023, págs. 768-775
  • Idioma: inglés
  • Texto completo no disponible (Saber más ...)
  • Resumen

    • Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 (“GRAVID”).

      Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021.

      Results One hundred-fifty cases were registered. Median age was 68 years (range 6–95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February–May 2020, August–November 2020, and December 2020–April 2021. The first wave had the highest number of registered cases and COVID-19 mortality.

      Conclusion Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection.

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