The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?

• Kuang-Qi Chen ^[1] ; Bang-Hong Wei ^[1] ; Shuang-Li Hao ^[1] ; Wan-Xi Yang ^[1]
  1. [1] Zhejiang University

     Zhejiang University

     China

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 37, Nº. 7, 2022, págs. 621-636
• Idioma: inglés
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• Resumen

  • The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and antiapoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis.