Mucormycosis infection associated with global COVID-19 pandemic - an institutional histopathological study

• R Keerthika ^[2] ; Anjali Narwal ^[3] ; Mala Kamboj ^[4] ; Anju Devi ^[5] ; Rahul Anand ^[6] ; Sivakumar N ^[2] ; Virendra Singh ^[1] ; Varsha Agarwal ^[7] ; Ambika Gupta ^[8]
  1. [1] King George's Medical University

     King George's Medical University

     India

     
  2. [2] MDS. Junior resident. Department of Oral and Maxillofacial Pathology and Microbiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India
  3. [3] MDS. Professor. Department of Oral and Maxillofacial Pathology and Microbiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India
  4. [4] MDS. Senior Professor and Head. Department of Oral and Maxillofacial Pathology and Microbiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India
  5. [5] MDS. Associate Professor. Department of Oral and Maxillofacial Pathology and Microbiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India
  6. [6] MDS, Assistant Professor, Department of Oral and Maxillofacial Pathology and Microbiology, D Y Patil Dental College and Hospital, Pune, Maharashtra, India
  7. [7] MDS. Junior resident. Department of Oral Medicine and Radiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India
  8. [8] MDS. Senior Professor and Head. Department of Oral Medicine and Radiology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, India

  Mostrar afiliaciones +
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 28, Nº. 2, 2023
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Coronavirus disease 2019 (COVID-19) in the recent times have instilled signs of immunosuppression globally which has further precipitated increasing range of opportunistic infections. Mucormycosis is a distressing opportunistic fungal infection with a high incidence and is the third commonest acute invasive infection following candidiasis and aspergillosis. The aim of the present observational study is to delineate the enigmatic histopathological profile between mucormycosis cases seen prior to pandemic (PPM) and pandemic associated mucormycosis (PAM).

    Tissue archives of 105 histopathologically diagnosed cases of mucormycosis were included and analysed for demographical details and histopathological parameters like fungal load and localization, granuloma formation, necrosis, inflammatory infiltrate and tissue invasion.

    0ut of 105 included cases, 11/105 (10.48%) were reported PPM and 94/105 (89.52%) PAM. Among 94 cases of PAM, 51/94 (54%) cases also showed COVID-19 positivity, while 43/94 (46%) did not. Of all the histological variables, increased fungal load and necrosis were observed in PAM relative to PPM cases.

    The histopathological variables like fungal load, necrosis, granuloma formation and tissue invasion, could help the clinician in assessing the clinical status at the time of tissue diagnosis and improve the treatment accordingly.