Evolution of hiv-1 viral load in patients followed-up for over 3 years
- Autores: José María Eiros Bouza, M. P. Ortega, A Mayo, C. Labayru, Raúl Ortiz de Lejarazu Leonardo
- Localización: Revista Electrónica de Biomedicina, ISSN-e 1697-090X, Nº. 1, 2006, págs. 26-32
- Idioma: varios idiomas
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Resumen
Objectives: To describe the evolution of a Human Immunodeficiency Virus Type 1 (HIV-1) infected patient cohort monitored for over 1,000 days.
Methods: HIV-1 Viral Load (VL), CD4/l lymphocyte values and antiretroviral therapies given to the patients were evaluated throughout the follow-up period. We present a retrospective descriptive study of the HIV-1 VL determinations performed on 369 individuals followed-up for over 1,000 days.
Results: The "non-detectable" VL (< 400 RNA copies/ml) percentage increased inversely with the decrease in VL above the detection limit (> 100.000 copies/ml) from the interval of 0-75 days up to the interval of 501- 1,000 days (t-test, p=0.005); at that point, results switched to the opposite.
Conclusions: Both CD4/ cell count lower than 200x106 and patients receiving highly active antiretroviral therapies (HAART) were related to "non-detectable" VL levels. In our series the time period between 700 and 1,000 days can be the maximum interval for benefits from therapy and virology evaluation.
