Resumen de Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells
Maryam Farzaneh, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Tariq Masoodi, Sajad Najafi, Mohadeseh Sheykhi-Sabzehpoush, Mahrokh Abouali Gale Dari, Klaudia Radoszkiewicz, Shahab Uddin, Shirin Azizidoost, Seyed Esmaeil Khoshnam
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
