Clinical Effect of Lamivudine Combined with Leflunomide and Methylprednisolone Tablets in the Treatment of Hepatitis B Virus-Associated Glomerulonephritis and Its Influence on Renal Function Indicators

• Houli Liu ^[1] ; Fen Jiang ^[2] ; Keke Zheng ^[3] ; Min Zhang ^[4] ; Xia Xing ^[5] ; Chuanneng Zhou ^[6]
  1. [1] Department of Clinical Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, 264100 Yantai, Shandong, China
  2. [2] Hepatology Department (I), Yantai Qishan Hospital, 264000 Yantai, Shandong, China
  3. [3] PICC Clinic, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, 266000 Qingdao, Shandong, China
  4. [4] Department of Health Management, Jinan Zhangqiu District People’s Hospital, 250200 Jinan, Shandong, China
  5. [5] Department of Gynaecology and Obstetrics, Zhangqiu District People’s Hospital, 250200 Jinan, Shandong, China
  6. [6] Public Health Section, Yantaishan Hospital, 264003 Yantai, Shandong, China

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• Localización: Archivos españoles de urología, ISSN 0004-0614, Tomo 76, Nº. 6 (August), 2023, págs. 403-410
• Idioma: inglés
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• Resumen

  • Background: In this study, the clinical effect of lamivudine combined with leflunomide and methylprednisolone in the treatment of hepatitis B virus-associated glomerulonephritis (HBV-GN) and their influence on renal function indexes was explored.

    Methods: Patients with HBV-GN were selected for retrospective analysis and divided into the group B and group A, with 41 cases in each group. The group B was given leflunomide and methylprednisolone, whereas the group A was supplemented with lamivudine. The level of 24 h proteinuria (PRO), albumin (ALB), beta2-microglobulin (β2-MG), alanine aminotransferase (ALT), interferon-gamma (IFN-γ) and interleukin-4 (IL-4) in two groups was measured. The clinical efficacy, adverse reactions appetite, spirit, sleep and daily life scores of the two groups were recorded.

    Results: With the extension of treatment time to end of the treatment, the level of 24 h PRO, ALB and β2-MG in the group A significantly changed compared with that before treatment (p < 0.05). Moreover, the level of ALT, IFN-γ and IL-4 in the two groups significantly decreased compared with that before treatment, and the level of the three indexes in the group A decreased more significantly (p < 0.05). The total effective rate in the group A was higher than that in the group B (p < 0.05). The occurrence of adverse reactions showed no statistically significant difference between the two groups. After treatment, scores of appetite, spirit, sleep and daily living were increased in the two groups, and the increase in the group A was more significant than that in the group B (p < 0.05).

    Conclusions: Lamivudine combined with methylprednisolone and leflunomide treatment is conducive to clearing Hepatitis B virus (HBV) and improving renal function.