Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective

Kamyar Nasiri; Masoud Amiri Moghaddam; Enas Abdalla Etajuri; Ashkan Badkoobeh; Omid Tavakol; Mohammadamin Rafinejad; Armita Forutan Mirhosseini; Amirhossein Fathi

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Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective

Kamyar Nasiri ^[1] ; Masoud Amiri Moghaddam ^[2] ; Enas Abdalla Etajuri ^[3] ; Ashkan Badkoobeh ^[6] ; Omid Tavakol ^[1] ; Mohammadamin Rafinejad ^[7] ; Armita Forutan Mirhosseini ^[4] ; Amirhossein Fathi ^[5]
1. [1] Islamic Azad University
  
  Islamic Azad University
  
  Irán
2. [2] Mashhad University of Medical Sciences
  
  Mashhad University of Medical Sciences
  
  Irán
3. [3] University of Malaya
  
  University of Malaya
  
  Malasia
4. [4] Kerman University of Medical Sciences
  
  Kerman University of Medical Sciences
  
  Irán
5. [5] Isfahan University of Medical Sciences
  
  Isfahan University of Medical Sciences
  
  Irán
6. [6] Department of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical Sciences, Qom, Iran
7. [7] Department of Dentistry, Borujerd University of Medical Science, Borujerd, Iran
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Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 10 (October), 2023, págs. 2801-2811
Idioma: inglés
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Resumen
- Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis.