Meta-analysis to implement alpha-synuclein in extracellular vesicles as a potential biomarker for parkinson’s disease

Víctor H. Juárez-Vaquera ^[1] ; Marcos F. Rosetti-Sciutto ^[2] ; Valeria Morales-Ruiz ^[1] ; Laura V. Adalid-Peralta ^[1]
1. [1] Instituto Nacional de Neurología y Neurocirugía
  
  Instituto Nacional de Neurología y Neurocirugía
  
  México
2. [2] Universidad Nacional Autónoma de México
  
  Universidad Nacional Autónoma de México
  
  México
Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 75, Nº. 4, 2023, págs. 193-202
Idioma: inglés
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Resumen
- In Parkinson’s disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker. Objective: Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency. Methods: Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis. Results: Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively. Conclusion: Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD. (REV INVEST CLIN. 2023;75(4):193-202)