Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: a systematic review

• Marcelle Farias Silva Monteiro ^[1] ; Jeanne Gisele Rodrigues de Lemos ^[2] ; Flávia Sirotheau Corrêa Pontes ^[3] ; Marcelle Farias Silva Monteiro ^[1] ; Misley Hellen Almeida Silva ^[4] ; Nathália Fernandes Silva ^[5] ; Lucas Lacerda de Souza ^[6] ; Daniel Cavallero Colares Uchôa ^[7] ; Hélder Antônio Rebelo Pontes ^[8]
  1. [1] ORCID: http://orcid.org/000-0003-2507-3823; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
  2. [2] ORCID: https://orcid.org/0000-0002-6691-3764; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
  3. [3] ORCID: https://orcid.org/0000-0002-1680-3102; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
  4. [4] ORCID: https://orcid.org/0000-0003-1539-3399; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
  5. [5] ORCID: https://orcid.org/0000-0003-4331-1864; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
  6. [6] ORCID: https://orcid.org/0000-0002-9481-7796; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
  7. [7] ORCID: https://orcid.org/0000-0002-3613-7071; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
  8. [8] ORCID: https://orcid.org/0000-0002-7609-8804; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil; 0ORCID: https://orcid.org/0000-0002-7609-8804; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 1 (January), 2024
• Idioma: inglés
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• Resumen

  • Graft-versus-host disease (GVHD) is an immune system reaction that occurs in patients with a history of hematopoietic stem cell transplantation (HSCT), in which the grafted donor's cells attack those of the host. The objective of this systematic review was to present a study on oral squamous cell carcinoma (OSSC) that developed from GVHD areas in patients undergoing HSCT.

    An electronic search was conducted in the databases PUBMED, WEB OF SCIENCE, SCOPUS, MEDLINE and SCIENCE DIRECT, according to PRISMA guidelines.

    Of the 1582 results, 23 articles were included, resulting in 81 cases. The most common underlying disease for performing the transplant was Myeloid Leukemia (55.6%). The mean age was 39 years, with a predilection for males (64.2%). The tongue was the site of GVHD that most frequently underwent transformation to SCC (59.3%). The average time between transplantation and the development of GVHD was of approximately of 8 months, while the average period of development between transplantation and the development of OSCC was of approximately of 111 months. The most common treatment to GVHD was cyclosporine associated with corticosteroids.

    OSCCs arising from areas of GVHD present a different evolution from conventional oral carcinomas, since they affect younger patients, smoking and alcohol are not important etiological factors and finally because they present good prognosis, but further studies with larger number cases followed are needed to confirm our findings.