Effect of medication therapy management on discharged patient with Ulcerative Colitis with initial stage biotherapy: a randomized study

• Qinbo Wang ^[1] ; Yuan Zhou ^[2] ; Guozeng Ye ^[3] ; Yingjuan Ou ^[3] ; Lihong Huang ^[3] ; Wenfeng Liu ^[3] ; Xiaoyan Li ^[3] ; Xia Wu ^[4]
  1. [1] Department of Pharmacy, The sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Graceland Medical Center, The sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  2. [2] Department of Gastroenterology, The sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  3. [3] Department of Pharmacy, The sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  4. [4] Department of Graceland Medical Center, The sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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• Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 21, Nº. 4, 2023 (Ejemplar dedicado a: Oct-Dec)
• Idioma: inglés
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  • Purpose: The aim of this study was to explore the effects of medication therapy management in improving perception, medication adherence, and disease control in UC patients with first-stage of biotherapy. Subjects and Methods: A total of 120 patients with UC who received first-stage biotherapy participated in this study. The patients were divided into MTM group and CFU group. Both groups received three times follow-up, which were carried out at first, third, and sixth discharged month, Group A was followed with the MTM method, and Group B received conventional follow-up. MDRKT was used to assess patient perception, adherence to treatment was assessed by MMSA-8, and we also explored disease control and patient satisfaction. Results: A total of 116 patients completed the survey, the MTM group showed a significant improvement in perception, 84.2% of patients can correctly handle ADEs and 82.5% of patients knew what to do when they leak medication, 87.8% of patients in the MTM group had better adherence than 71.2% in the CFU group (P<0.05). The evaluation of disease control showed that 56.1% of patients in the Group A were in remission which was significantly higher than 32.2% in the Group B (P<0.05). Furthermore, the result of the questionnaire survey showed that perception, ADE, self-management, anxiety, and satisfaction were better in the MTM group than in the CFU group (P<0.05). Conclusion: The MTM group was effective in improving medication adherence, perception, and satisfaction in the patient with ulcerative colitis treated with first-stage biotherapy, and the disease control significantly improved