Synthesis, chemical identification, drug release and docking studies of the amlodipine–chitosan nanobiopolymer composite

• Autores: Rodrigo Ramirez Tagle, Guillermo Salgado Morán, David Mendez-Luna, José Correa-Basurto, Wilson Cardona Villada, Lorena Gerli-Candia, L.H. Mendoza Huizar
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 66, Nº. 1, 2021, págs. 5063-5066
• Idioma: inglés
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• Resumen

  • A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.