Resumen de Synthesis of 6- tert -octyl and 6,8-di tert -butyl coumarins, two coumarins of biological interest

M. Zárraga O., M. Darouch, E. Lisboa, P. Arroyo P., A. Miranda M.

• In this study, the synthesis of new coumarins with aliphatic chains is discussed. The incorporation of the 6- tert -octyl and 6,8-di tert -butyl chains into a coumarin structure from alkylphenols, allows obtaining hydrophobic coumarins with good yields. These coumarins can be potential modulators of TRPV1 receptors. Synthesis and spectroscopic data of these new coumarins are analyzed.