Synthesis, quality control and biodistribution of techneium-99m triamcinolone acetonide (99mtc-ta) complex: An inflammation tracer agent
-
FAHEEM ASKARI RIZVI [2] ; SYED ALI RAZA NAQVI [2] ; MUHAMMAD MEHDI [2] ; SAMINA ROOHI [1] ; AMEER FAWAD ZAHOOR [2] ; ZULFIQAR ALI KHAN [2] ; MUHAMMAD SOHAIB [3] ; RASHID RASHEED [2]
-
[1] Pakistan Institute of Nuclear Science and Technology
Pakistan Institute of Nuclear Science and Technology
Pakistán
-
[2] Government College University Faisalabad Department of Chemistry
-
[3] Pakistan Institute of Engineering and Applied Sciences Department of Medical Sciences
-
- Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 62, Nº. 1, 2017, págs. 3345-3349
- Idioma: inglés
- Enlaces
-
Resumen
In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44 ± 1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases.
