New spectrophotometry method for the determination of mirtazapine in pharmaceutical formulations

• FOZIA REHMAN ^[2] ; SAIMA GUL ^[3] ; SAJJAD HUSSAIN ^[4] ; SABIR KHAN ^[1]
  1. [1] Universidade Estadual Paulista

     Universidade Estadual Paulista

     Brasil

     
  2. [2] Institute of Information Technology Interdisciplinary Research Centre in Biomedical Materials
  3. [3] University of Swabi for Woman Gulo-Deri Department of Chemistry
  4. [4] GIK Institute of Engineering Sciences & Technology Faculty of Materials & Chemical Engineering

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 61, Nº. 2, 2016, págs. 2913-2915
• Idioma: inglés
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  • A simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully applied to the determination of mirtazapine in their pharmaceutical formulations. The method shows a linear range from 0.2-10 μg mL-1 with a molar absorptivity of 1.53 '10 4 L mol-1 cm-1. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.096 μg mL-1 and 0.32μg mL-1 respectively. The developed methodology was successfully applied for the determination of mirtazapine in commercial formulation and the percentage recovery was found 99.91 ± 0.15. The developed methodology promises a feasible, low cost and an efficient method for the routine analysis.