Resumen de Synthesis and antifungal activity of diaryl hydrazones from 2,4-dinitrophenylhydrazine
Sergio Ortiz, Ronald Nelson, Victor Hugo Kesternich Martinez, Marcia Pérez-fehrmann, Philippe Christen, Laurence Marcourt
A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.
