Kinetics and mechanistic study of oxidation of amoxicillin by chloramine-t in acid medium

• M. S VEENA ^[1] ; M. K PRASHANTH ^[2] ; K YOGESH KUMAR ^[3] ; H. B MURALIDHARA ^[4] ; Y ARTHOBA NAYAKA ^[5]
  1. [1] K.S. Institute of Technology Department of Chemistry Centre for Nanosciences
  2. [2] P.N.S. Institute of Technology Department of Chemistry
  3. [3] Jain University School of Engineering and Technology Department of Chemistry
  4. [4] Jain University Centre for Emerging Technologies
  5. [5] Kuvempu University School of Chemical Sciences Department of PG Studies and Research in Chemistry

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 3, 2015, págs. 3063-3068
• Idioma: inglés
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  • This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. The order with respect to acid concentration was fractional. The effects of added products, ionic strength and dielectric constant have been studied. The main oxidation product of AMOX was identified by IR, ¹H NMR and mass spectra. The reaction constants involved in the different steps of the mechanisms were calculated. Activation parameters with respect to slow step of the mechanisms were computed and discussed.