Synthesis, crystal structure and antioxidant potential of di-(tv-cinnamyl) fluoxetine chloride

• NOSHEEN KANWAL ^[1] ; ONUR SAHIN ^[2] ; ERUM A HUSAAIN ^[1] ; ISLAM ULLAHKHAN ^[3] ; ORHAN BUYUKGUNGOR ^[2]
  1. [1] Lahore College for Women University

     Lahore College for Women University

     Pakistán

     
  2. [2] Ondokuz Mayis University Faculty of Arts and Sciences Department of Physics
  3. [3] GC University Department of Chemistry

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 1, 2013, págs. 1508-1512
• Idioma: inglés
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• Resumen

  • A new derivative of Fluoxetine, N,N-dicinnamyl-N-methyl-3-phenyl-3- [4-(trifluoromethyl) phenoxy]butan-1-aminium chloride hydrate [Di-(N-Cinnamyl) Fluoxetine Chloride hydrate] was synthesized and characterized by single-crystal X-ray diffraction studies, elemental analyzer, thermogravimetric and FTIR spectroscopy analysis. The titled compound [C35H37ClF3NO2] crystallized in monoclinic, having unit cell parameters a = 19.155(14) A°, b = 9.193(5) A°, c = 18.596(13) A° and belongs to P2(1)/c space group. The molecule shows disorder of F atoms and was modeled as two different orientations. The one-dimensional crystal packing features weak C-H … π interactions showing the formation of a chain along [001], provides stability to the crystal lattice. Antioxidant potential of Di-(N-Cinnamyl) Fluoxetine Chloride hydrate has been described and was found higher than Fluoxetine and N-Benzyl Fluoxetine.