¹h and 13c nmr spectral assignments and x-ray crystallography of 4,5,8,12b-tetrahydro-isoindolo[1,2 -α ]isoquinoline and derivatives

• VICENTE CASTRO-CASTILLO ^[2] ; ANTONIO GALDÁMEZ ^[1] ; MARCO REBOLLEDO-FUENTES ^[1] ; BRUCE K CASSELS ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Metropolitan Educational Sciences University Faculty of Basic Sciences
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 57, Nº. 1, 2012, págs. 972-976
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • 12b-Hydroxy-5,6,8,12b-tetrahydroisoindolo[1,2-α] isoquinolin-8-one (4), 5,6,8,12b-tetrahydroisoindolo[1,2-α]isoquinoline (5) and 12b-hydroxy-5,6,8,12b-tetrahydroisoindolo[1,2-α]isoquinoline (6) were obtained by reduction of 4,5,8,12b-tetrahydroisoindolo[1,2-α]isoquinolin-8-one (3) with LiAlH4/THF/N2. The precursor and products were characterized by NMR spectroscopy and the X-ray crystal structure of 5 hydrochloride monohydrate (5a) was determined. ¹H and 13C NMR spectra were completely assigned for compounds 3, 4, and 5a, using two-dimensional experiments (H-H COSY, HMQC, HMBC and H-H NOESY).