Solvent free oxalic acid catalyzed synthesis of 1,5-benzodiazepines

• ANIKET P SARKATE ^[1] ; JAIPRAKASH N SANGSHETTI ^[2] ; NANASAHEB B DHARBALE ^[3] ; AJINKYA P SARKATE ^[4] ; PRAVIN S WAKTE ^[1] ; DEVANAND B SHINDE ^[1]
  1. [1] Dr. Babasaheb Ambedkar Marathwada University Department of Chemical Technology
  2. [2] Y. B. Chavan College of Pharmacy Department of Pharmaceutical Chemistry
  3. [3] Shri Bhagwan College of Pharmacy Department of Pharmaceutical Chemistry
  4. [4] Sinhgad Institute of Pharmacy Department of Pharmaceutical Chemistry

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 4, 2013, págs. 2200-2203
• Idioma: inglés
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  • In the present study 1, 5-benzodiazepines were synthesized from a range of α, β-unsaturated ketones and o-phenylendiamine using oxalic acid 10 mol% as a catalyst under solvent free conditions. The yields of the present method are better than the reported method which explains effectiveness of oxalic acid catalyst. The cost effective, resourceful, undemanding and environment friendly are the advantageous aspects of this method.