New approaches for the synthesis of hydrazone derivatives and their antitumor evaluation

• WAGNAT WAHBA WARDAKHAN ^[1] ; EMAN MOHAMED SAMIR ^[1]
  1. [1] National Organization for Drug Control & Research
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 57, Nº. 2, 2012, págs. 1118-1121
• Idioma: inglés
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• Resumen

  • The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.