Resumen de Biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives
A Cañete, F Armijo, María Angélica del Valle, R.a Tapia, Cristina Theoduloz, C. D Pessoa, L Cantuarias, G Recabarren
We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.
