Carbon-based solid acid catalyzed synthesis of polyhydroquinoline derivatives via hantzsch reaction under solvent-free conditions

ABOLGHASEM DAVOODNIA ^[1] ; AMIR KHOJASTEHNEZHAD ^[1]
1. [1] Islamic Azad University
  
  Islamic Azad University
  
  Irán
Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 57, Nº. 4, 2012, págs. 1385-1387
Idioma: inglés
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Resumen
- An easy method for the synthesis of polyhydroquinoline derivatives via one-pot four-component Hantzsch condensation of dimedone, aryl aldehydes, ethyl acetoacetate and ammonium acetate in the presence of a catalytic amount of carbon-based solid acid (CBSA) in solvent-free conditions is described. The main advantages of the present approach are relatively short reaction times, high product yields, clean reaction profiles, simple experimental and work-up procedure.