Anodic synthesis, spectral characterization and antimicrobial activity of novel 2-amino-5-substituted-1,3,4-oxadiazoles

• SANJEEV KUMAR ^[1]
  1. [1] University of Allahabad

     University of Allahabad

     India

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 1, 2010, págs. 126-129
• Idioma: inglés
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• Resumen

  • Synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles through the electrochemical oxidation of semicarbazone was carried out at platinum anode at room temperature under controlled potential electrolysis in an undivided cell assembly. The electrolysis were carried out in the non aqueous medium acetic acid and lithium perchlorate was used as a supporting electrolyte. The antimicrobial activities of the compounds have been studied by screening the compounds against two gram negative organisms Klebsiella pneumoniae, Escherichia coli, and two gram positive organisms Bacillus subtilis and Streptococcus aureus and antifungal activity against Aspergillus niger and Crysosporium pannical and results have been compared with the standard antibacterial Streptomycin and antifungal Griseofulvin.