Synthesis of 1-benzyl-3-[4-(aryl-1-piperazinyl) carbonyl]-1h-indoles: Novel ligands with potential d4 dopaminergic activity

• HERNÁN PESSOA-MAHANA ^[1] ; IGNACIO CUEVAS M ^[1] ; C. DAVID PESSOA-MAHANA ^[1] ; RAMIRO ARAYA-MATURANA ^[1] ; IRIUX ALMODOVAR FAJARDO ^[1] ; CLAUDIO SAITZ BARRÍA ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 4, 2011, págs. 866-869
• Idioma: inglés
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• Resumen

  • The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield.