Theoretical model of aldolase fructose 1,6 biphosphate from trypanosome brucei

• MARYI CORDERO DE TROCONIS ^[1] ; TRINA COLMAN ^[1] ; MARGOT LEDEZMA DE RUIZ
  1. [1] Universidad Central de Venezuela

     Universidad Central de Venezuela

     Venezuela

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 3, 2010, págs. 298-300
• Idioma: inglés
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• Resumen

  • Parasites from the Trypanosomatidae family cause different illnesses in human and animals. Drugs currently in use against them have limited efficacy and high toxicity, therefore is very important that scientists continue their efforts to look for new targets for the treatment of these diseases. Trypanosome brucei is the causal agent of African trypanosomiasis (sleeping sickness) in human and animals, and is one of the trypanosome species that are actively investigated. Trypanosomes in the blood depend entirely from the glycolisis in order to obtain energy, so this is one of the possible points of attack. The aldolase fructose biphosphate seems to be until now the regulator of the glycolisis so its study is very important. The modeled three-dimensional structure of aldolase fructose biphosphate from Trypanosome brucei was obtained using the program Modeller based on the sequence previously published by Clayton. This modeled structure will help as a starting point for future rational chemotherapy studies, and the methodology described could be used for other enzymes of unknown three dimensional structures.