Synthesis and in vitro antimicrobial activity of some triazole derivatives

• RAVINESH MISHRA ^[1] ; RAJIV KUMAR ^[1] ; SURESH KUMAR ^[1] ; JASEELA MAJEED ^[1] ; MOHD RASHID ^[1] ; SAMEER SHARMA ^[1]
  1. [1] Hamdard University

     Hamdard University

     Pakistán

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 3, 2010, págs. 359-362
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazol (3a- 3f) and N-[5-(4-substituted)-1H-1,2,3-triazol-1-yl] isonicotinamide derivatives (5a- 5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and 2. The antibacterial and antifungal activities of newly synthesized compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus niger and Candida albicans. Ciprofloxacin and Fluconazole at 50 µg/mL were used as standard drugs for antibacterial and antifungal activities, respectively. All the synthesized compounds showed significant activity against various microorganisms.