Resumen de Secondary metabolites from the culture broth of actinomycete acrocarpospora sp. Firdi 001 and their antimicrobial activity
Ming-jen Cheng, Hui-Min Tseng, Ih-Sheng Chen, Chii-cherng Liao, Gwo-fang Yuan
Two natural new compounds, pyrroline-2-one (1) and 2-(2-amino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionic acid (2), together with nine known compounds, iodinin (3), thymine (4), V-(2-hydroxy-phenyl)-acetamide (5), (Z)-pulchellalactam (6), uracil (7), nicotinic acid (8), nicotiamide (9); p-nitrophenol (10) and indole 3-carboxylic acid (11), all were isolated from the EtOAc extract of the culture broth of anew actinomycete Acrocarpospora sp. strain, FIRDI 001. The structures were elucidated by ID and 2D NMR spectroscopy and mass spectrometry. Furthermore, the isolated compounds were subjected to evaluate the antimicrobial activity. Compounds 2, 3 and 10 showed antimicrobial activity. The active metabolite, iodinin existed as a major metabolite in this study.
