Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple

• Autores: María Eugenia Legües, Paulina Morales, Mercedes Valenzuela, Andrea Encina, María José Martí, Claudia Bascuñán, Paulina Cornejo, Camila Peña, María Soledad Undurraga
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 147, Nº. 1, 2019, págs. 61-64
• Idioma: español
• Títulos paralelos:
  • High risk cytogenetic abnormalities in patients with multiple myeloma
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• Resumen

  • Background: Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification. Aim: To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t(14;16) and del(17p) in Chilean patients with MM. Material and Methods: We studied 30 patients with MM by conventional cytogenetics (CC) and fluorescent in situ hybridization of plasma cells selected using cytoplasmic immunoglobulin staining (cIg-FISH). Results: Overall, the two techniques in combination allowed us to identify clonal genetic abnormalities in 47% of patients. The t(4;14) abnormality was observed in 19% of patients, del(17p) was observed in 10% of patients, and t(14;16) was not detected. Conclusions: Our results showed frequencies of high-risk abnormalities similar to those reported abroad. Cytogenetic studies should be performed routinely for all MM patients at the moment of diagnosis.