Synthesis of 2-aryl-1,3-propanediamines using a one-pot knoevenagel-michael sequence

• PATRICIO ITURRIAGA-VÁSQUEZ ^[1] ; SUSAN LÜHR-SIERRA ^[1] ; MARCOS CAROLI REZENDE ^[2] ; BRUCE K CASSELS ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Universidad de Santiago Facultad de Química y Biología Departamento de Química
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 51, Nº. 1, 2006, págs. 781-783
• Idioma: inglés
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• Resumen

  • A simple synthetic route for the preparation of 2-phenyl-1,3-propanediamines, based on a Knoevenagel-Michael double condensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium bicarbonate as base in the first step, followed by catalytic hydrogenation over Adams catalyst