Resumen de Synthesis and coordination properties of chiral bidentate p,o-donor ligands

Oscar Díaz, Raul Contreras, Mauricio Valderrama

• Reaction of the chiral compound (S)-(+)-BrCH2CHMeCH2OH with Ph2PK in the presence of lithium diisopropylamide (LDA) and BH3/THF yields the monophosphine (S)-Ph2P(BH3)CH2CHMeCH 2OH(1). The reaction of 1 with ClOSO2Me/Et3N or NaH/MeI gives rise to the formation of the general compound (S)-Ph2P(BH3)CH2CHMeCH 2OR [Cp*IrCl2(PPh2CH2CHMeCH 2OR-P)], which by treatment with pyrrolidine affords (S)-Ph2PCH2CHMeCH2 OR [R = SO2Me (4), Me (6)]. The monophophines 4, 6 and (S)-PPh2CH2CHMeCH2 OH react with [{Cp*IrCl(µ-Cl)}2] to give the neutral compounds [Cp*IrCl2(PPh2CH2CHMeCH 2OR-P)], where only the compound with R = H (7) was fully characterized. Complex 7 reacts with AgBF4 yielding the cationic complex [Cp*IrCl(PPh2CH2CHMeCH2 OH-P,O)]BF4 (8) in which the ligand acts in its bidentate form. Similar synthetic results were obtained using [{Cp*IrI(µ-I)}2] as starting complex .