Synthesis and antibacterial activity of cefotaxime metal complexes

• J.R. Anacona ^[1] ; Gladys Da Silva ^[1]
  1. [1] Universidad de Oriente

     Universidad de Oriente

     Venezuela

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 50, Nº. 2, 2005, págs. 447-450
• Idioma: inglés
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• Resumen

  • Cefotaxime (Hcefotax) interacts with transition metal ions to give [M(cefotax)Cl] complexes (M = Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Cd(II)) which were characterized by physicochemical and spectroscopic methods and a tetrahedral geometry is suggested for their structure. The IR and the ¹H-NMR spectra of the complexes suggest that the cefotaxime behaves as monoanionic tridentate ligand . The complexes have been screened for antibacterial activity against several bacteria, and the results are compared with the activity of cefotaxime