Synthesis of novel neonicotinoids derivatives

• González-Gutiérrez, juan pablo ^[1] ; Moris, Silvana ^[2] ; Barrientos, Claudio ^[3]
  1. [1] Universidad Autónoma de Chile

     Universidad Autónoma de Chile

     Temuco, Chile

     
  2. [2] Universidad Católica del Maule

     Universidad Católica del Maule

     Provincia de Talca, Chile

     
  3. [3] Universidad Autonoma

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 68, Nº. 3, 2023 (Ejemplar dedicado a: Journal of the Chilean Chemical Society), págs. 5901-5903
• Idioma: inglés
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• Resumen

  • Neonicotinoid compounds have been used as insecticides since the 1990s to effectively control Hemipteran pests such as aphids, leafhoppers, whiteflies, and additionally, for their lethal activity and low toxicity in humans. The synthesis of novel neonicotinoids compounds was achieved using (S)-(-)-(1-methyl-2-pyrrolidinyl)methanol and (±)-2-(1-methyl-2-pyrrolidinyl)ethanol with nitrobenzoyl chlorides derivatives in diethyl ether at room temperature to concentrate in vacuum to subsequently neutralize (pH = 8) with 7.4% (w/v) isopropanol HCl solution to obtain hydrochloride salts. (S)-(1-methyl-2-pyrrolidinyl)methyl and (±)-2-(1-methyl-2-pyrrolidinyl)ethyl 2-nitrobenzoate salts was not possible to form.