Acidosis láctica asociada a metformina. Caso clínico

• Autores: Felipe Quintana, María José Pezzani, Rodrigo Orozco, Jorge Dreyse, Leonardo Soto, Tomás Regueira
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 145, Nº. 8, 2017, págs. 1072-1075
• Idioma: español
• Títulos paralelos:
  • Metformin-associated lactic acidosis. Report of one case
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• Resumen

  • Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind.